Smoking freebase cocaine creates a more powerful effect more rapidly, but it is also more dangerous because the safe dose can easily be exceeded.
Salvia is a potent and legal drug that can easily be obtained in many stores across the U.S. which sell tobacco products.
Opiates activate opiate receptors that are widely distributed throughout the brain and body which are part of the body's natural reward system and also relieve pain.
Over the past quarter of a century, recreational use of marijuana has increased significantly and has come to be considered by large numbers of young people as a normal leisure activity.