Sudden cessation of chronic and extensive alcohol use will very likely produce withdrawal symptoms, including severe anxiety, tremors, hallucinations and convulsions.
Irreversible effects caused by inhalant abuse can include hearing loss, limb spasms, central nervous system or brain damage, or bone marrow damage.
Women are unable to metabolize alcohol as efficiently as men because they have less of a liver enzyme (dehydrogenase) that converts alcohol into an inactive substance.
Rates of LSD use decreased dramatically during the 1980's, but increases again during the early 1990's.