Alcoholics continue to work and socialize reasonably well, their deteriorating physical condition may go unrecognized by others until severe damage develops - or until they are hospitalized for other reasons and suddenly experience alcohol withdrawal symp
When someone has taken a particularly large dose of opiates they may not be able to be awakened, their pupils become smaller, and their skin becomes cold, moist, and bluish in color. Breathing slows and death can occur.
Out of all Ecstasy related emergency department visits in 2008, involving Ecstasy in combination with alcohol or other drugs, over 30% involved Ecstasy with one other drug, 15.0 percent involved two other drugs, 14.0 percent involved three other drugs, and 17.5 percent involved four or more other drugs.
When addicted individuals stop using cocaine, they often become depressed which may lead to further cocaine use to alleviate depression.