When taking into account the negative health consequences and trafficking related violence as measuring tools, cocaine is just behind heroin as the second most problematic drug in the world.
Out of all Ecstasy related emergency department visits in 2008, involving Ecstasy in combination with alcohol or other drugs, over 30% involved Ecstasy with one other drug, 15.0 percent involved two other drugs, 14.0 percent involved three other drugs, and 17.5 percent involved four or more other drugs.
The effects which result from the ruse of amphetamines are similar to cocaine.
Methamphetamine produces more extensive and pronounced effects on the brain and central nervous system than cocaine or amphetamine.