As part of withdrawal from these drugs after sudden cessation of use, sedatives and benzodiazepines can cause rebound insomnia when used regularly to aid sleep.
When cocaine users stop using cocaine, or when they end a cocaine binge, they almost immediately feel the "crash" which includes depression, fatigue, lack of pleasure, anxiety, irritability, sleepiness and a strong craving for more cocaine.
Use of amphetamines can cause psychological effects which can include a feeling of well-being and great alertness and energy.
Salvia affects the kappa opioid receptors in the brain, which causes brief but intense hallucinations and a sense of disconnection from reality.