When people mix cocaine and alcohol the dangers associated with the use of these substances are compounded, and the human liver combines cocaine and alcohol and manufactures a third substance, cocaethylene, which intensifies cocaine's euphoric effects while also increasing the risk of sudden death.
Physical drug withdrawal can cause confusion, disorientation, excessive sleepiness and seizures.
Some Ecstasy users may become dehydrated through vigorous activity in a hot environment.
Methamphetamine is a neurotoxin which means that the drug can and does cause damage to the central nervous system.