Some magic mushroom users report a "what have I done to myself" or "how far am I going" feeling.
Women who consume in excess of one alcoholic drink per day increase their risk for motor vehicle crashes.
Opiates act directly on the respiratory center in the brainstem, causing a slow in activity resulting in a decrease in breathing rate.
Women and low-body-weight males have a lesser capacity to break alcohol down in the same amount of time as a heavier male or female, resulting in higher blood alcohol concentration.