When cocaine is injected, the high can last from 15 to 30 minutes.
The same exact dose of Methadone could be ineffective for one person, but could also cause a deadly overdose for someone else who isn't tolerant to that dose.
Vicodin overdose can occur both in individuals who have been legitimately prescribed the drug, and in individuals who abuse it illegally.
The physical effects include increased body temperature, heart rate, and blood pressure; sleeplessness, and loss of appetite.