Studies indicate that drinkers who are able to handle a lot of alcohol in one drinking episode are at higher risk of developing alcohol dependence.
Opiate dependence even after short term use is can develop especially if a person uses a lot of opiates or even uses opiates occasionally over a long period of time.
The possibility of a "bad trip" LSD trip can be reduced by taking the drug only when in a positive state of mind and in a relaxed environment.
Narcotic pain medications, such as Vicodin or OxyContin, put individuals at risk for of serious consequences similar to illicit opioids such as heroin.