Methamphetamine impairs the ability and the desire to be safe which could lead to riskier activity and behaviors, not just sexually but in general.
Research has found that alcohol consumed before a meal increases caloric intake to a far greater extent than a non-alcoholic carbohydrate drink.
It is unlikely that individuals who wish to stop using Methadone will be able to quit on their own or complete a methadone withdrawal on their own or at a methadone clinic, and many individuals give up on ever being able to withdraw from the drug.
Smoking freebase cocaine creates a more powerful effect more rapidly, but it is also more dangerous because the safe dose can easily be exceeded.