Large amounts of dopamine in the brain as a result of a methamphetamine may lead to irreparable brain damage, because the drug destroys natural dopamine production sites.
Whether an individual is taking fentanyl legitimately or illicitly, it is very easy to develop dependence to the drug which requires daily use.
Serious medical or mental illness as well as criminal involvement may increase the likelihood of individuals prematurely leaving drug rehab, in which case intensive interventions may be required to retain them.
The total number of drug-related emergency room visits rose over 80 percent from 2004 (2.5 million) to 2009 (4.6 million).