Methadone users often begin experiencing severe withdrawal symptoms three to four days after the last dose.
The use of methadone is sometimes associated with the debilitating bone and joint pain that is often experienced during opioid withdrawal.
Some Ecstasy users experience many unwanted side effects including feelings of sadness, anxiety, depression, and memory difficulties which can last for several days to a week.
Vermont has the highest rate of marijuana use out of all States among individuals aged 12 to 17 (10.4), while New Hampshire has the highest rate among individuals aged 18 to 25 (11.1).