There are some instances of individuals high have been high on LSD who attempt to walk through traffic while hallucinating; these incidents have resulted in numerous accidental injuries and cases of death.
Studies indicate that long-term methamphetamine use may result in extensive damage to the serotonin-containing nerve cells in the body, leading to long-term sleep deprivation.
Mixing alcohol with certain medications often causes nausea and vomiting, headaches, drowsiness, fainting, or loss of coordination.
The illegal use of anabolic steroids is so widespread that it has affected the outcome of many sports contests, including the Olympics.